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The isolated nucleic acid of claim 1, gainly flonase cost 2, or 3, wherein the encoded modified tetracycline repressor binds to a tetracycline operator sequence in a prokaryotic organism with a greater affinity in the presence of tetracycline or a tetracycline analog than in the absence of tetracycline or the tetracycline analog with a greater affinity at 37° C!

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